Down Syndrome Complicating Synchronous Endometrial and Salpinx Cancer. Presentation of a Rare Case and Mini-Review of the Literature

There are only a few reports of uterine cancers in women with Down syndrome, whose tumor profile is marked by a reduced risk for solid neoplasms.

In our case, an early diagnosis of metastaticsynchronous endometrial cancer stage II in the anatomic area of salpinx and stage III in endometrial cavity was confirmed in a 55-year-old, nulliparous, menopausal, obese woman with Down syndrome, presented with irregular vaginal bleeding.

Although uterine cancers are underrepresented in women with Down syndrome, uterine malignancy should be considered in differential diagnosis of abnormal vaginal bleeding.

Our goal remains, proper diagnosis and treatment followed by assiduous therapeutic mapping.

Keywords: Down Syndrome, Trisomy 21, Endometrial Cancer, Uterine Cancer.